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Interesting to see quite a few responses to my enquiries about co cause of PD. Do any of you who beleive PD caused by co have or had any other autoimmune diseases? In re-ply to Vit. E I have taken 2000 units per day for 7 years no effects on the medications I have taken during these years but beleive maybe has helped with the slow progress of PD.I also have taken Eldepryl 2x5mg. for same time my neuro was to change me over to Tasmar this month but is not happy with results from other patients recently taking this medication.So sticking with Eldepryl.I am finding Mirapex is making me feel much better physically and mentally over Permax.although not appearing to extend ontime.also take sinemet cr and sinemet regular have a good day Margaret