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Dear Lisa, Back when levodopa alone was the medication for PD, it was found that B6 interfered with its absorption. With the combination of levodopa-carbidopa, this interference was to a great extent done away with. However, many experts believe that enough B6 could still overwhelm the levodopa. It may be that Dr. Iacono suggested taking the levodopa well before bedtime, then taking the B6 separately just before bed. This would allow the levodopa to be absorbed before the B6 arrived at the intestine. Wish I could have heard him speak! I've heard so much about him via this list, I'd give a bunch to meet him in person. Best regards, Kathrynne LCarper wrote: > Hi, > One of the things Dr. Iacono talked about Wed night was B6 for PWP and he was > very specific about taking it at night. B6 is an 'energizer' (I > thought)....does anyone know why Iacono would specify taking it a night since > it's supposed to energize you???? Besides wanting to know this for Jeff's > benefit, I'd like to know as well-I take a B100 combo. > Regards, > Lisa Carper > (wife of Jeff 47/9) -- Kathrynne Holden, MS, RD "Nutrition you can live with!" Medical nutrition therapy http://www.nutritionucanlivewith.com/ Tel: 970-493-6532 // Fax: 970-493-6538