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hi I was graduated from permax to mirapex over a 4 month period due to permax started after 8 years giving me side effects. It took another month for adjustment of on and off times by adding regular sinemet to my sinemet cr.unfortunately sinemet has not been reduced .quality of on time is definitely improved but not increased, my well being has definitely improved. Schedule 7.30am 1xsinemetCR50/200 1/2xsinemt25/200 1xelderpryl5mg 1 1/2mirapex 12.30 " " " " 6pm " 0 0 " 10pm " 0 0 0 10pm " I have always taken all medication together in the amounts and times shown.It seeems to have worked for me. I am one of those people who needs the sinemet at night to help calm the tremour in leg to help may be the four hours sleep I can get !!!!!I did cut back on the 1/2 sinemet in the evening as I found the dyskinisia was increased but neede the booster for first part of day. As we all know designer disease PD is different for each individual Good luck with Mirapex Have a good day Margaret