I am taking Mirapex and Sinemet as follows: At 6:30 am: 1 - Sinemet CR 50/200 1/2 - Sinemet 10/100 1 - Mirapex 1 mg At Noon: 1 - Sinemet CR 50/200 1/2 - Mirapex 1 mg At 5:30 pm: 1/2 - Sinemet CR 50/200 1/2 - Mirapex 1 mg I hsve been experiencing more "Off" times recently. I go to see my neurologist on Monday, so will see if he changes the dosages any. Mary Watkins ([log in to unmask])