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On Sun 10 May, paul s mccahan wrote: > What I WANT IS A WAY TO get thru the night better....Like when I have a > prostrate gland like a 20 yr old, why do I have to pea so much? Why > do I feel like I wired....a feeling that is hard to describe; a;; I can > say is that it is in tollerable at times....some times I can make the > spasoms go away by by certain breathing exercises. > > `I take meds 8X/day. 5:45, 8:00, 10:30, 1:00 pm, 3:15, 5:45pm, > and 8:00pm. At > these times I take two, 25/100 carbidopa/levidopa. At 5:45, 1:00 > and 8:00pm I take mirapex 4.5mG./day. The neuro I'm using for Rx's > doesn't seem to know what to do. > > Movemenrt t Problem: > > I have trouble "bending the knee" when I'm off and trying to walk > somewhere. Bending the knee = lifting the leg when walking. I think > I can't do it...but if I stop and deloiberatly concentrate on my left leg > I CAN LIFT IT. > > At this point my wife calles me a demented liar. > > I was diag. in 1991 and I'm 65 . > Please help, Paul > > [log in to unmask] > > > Hello Paul, my 'instant reaction' to your meds is that you are taking far too much Sinemet for a single dose, and then waiting too long before the next dose. This is a practice which can easily result in a drug- induced see-saw where you swing from Off, to On, to Overdosed and back again at the same rate. Your total drug intake per day is very high. and I would suggest that you try to reduce it. I don't know what is the safe maximum dose of Mirapex, but if you are allowed more, it would be much better if you could back -off the Sinamet, and increase the Mirapex. For night-time I would suggest that you only take HALF the quantity of Sinemet per hour as you take during the day. I would suggest that you start this 1 tablet routine at 8.00pm (That may turn out to be a little early), and then if you wake at night, take a single 25/100 tablet, but try to stick to the rule of at least 2 hours between tablets. re-starting the daytime doses at 5.45am. I hope that helps a little. Regards, -- Brian Collins <[log in to unmask]>