Dear AWalsh, I'm no doctor but I'm a well experienced medication taking patient and I think your neuro may be incorrect when he says that your husband should not take any of the other drugs in the same class as Mirapex. The agonists may in fact be interchangeable so when one doesn't work another may well. So I would inquire about using Requip Prior to switching to Mirapex I was tried on Parlodel which was horrible for me but I tolerated Permax quite well. The Parlodel and the Permax are both ergot derivative dopamine agonists so why one works and the other doesn't remains a riddle to me But check around. I may be entirely wrong or I may be right Good luck george