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This is [log in to unmask] 13 Bi Pallodotomys Started Tasmar Apr l5,98. I am truly impressed by tasmar. It is definitely proving to be the most effective medication I,ve used to date. However I'm also concerned about its possible side effects. I,m getting the recommended blood test for the liver. I'm on 100 mg three times daily. along with sinemet 10/100. Before Tasmar I was on maripex a maximum effective dose of 3 tabs 3 times a day my experience with maripex was that I needed increased amounts of sinemet to maintain my fluctuating on times. @While on the maripex in had to increase my sinemet from 1200 mg to about 2400 mg I tapered off the maripex completely before I started tasmar. Tasmar allowed me to adjust my sinemet to 1400 to 1600mg I'm also making an effort to reduce the carbadopa by going to 10/100 sinemet. I started with 25/100 sinemet and experienced great results . My worst problem was not being able to sleep. I credit the cut back in carbidopa and the use of oxybutynin 5 mg 1/2 tap 3 times a day with relief of my sleep problem. If I remember right. Carbidopa is needed in a range of 75 to 300 mg.to be effective. any less or any more can limit effectiveness or cause excess problems. I'm very happy with the quick response tasmar gives.. I seem to be very sensitive to Tasmar, but it is taken 6 hours apart. My response seems to last only 4 hours. with the 100 mg dose. I follow the same avoidance of protein high foods.and follow a 3 hour dosing interval , this is right for me at this time. This is a good working schedule. Don.t give up/ find a cure Bob Langer. mn 5-19=98 Please let me know of any and all possitive and negative you feel when taking Tasmar for an extended amount of time. Best Wishes to all .