Hi Margaret, With regard to agonists, I went onto Pergolide after = about five years of just taking Madopar (Sinemet eqvt') and selegiline = (Eldepryl).I stayed with the pergolide for about four years, although I = was never convinced that it was actually doing me any good, as I could = not pin down any benefits. However all this changed when I saw my Neurolo= gist, and mentioned to him that I was'nt happy with pergolide, and could = I try a new agonist which had just recently been released here in the UK,= called Cabaser (Cabergolide). This was the best thing since sliced bread= was invented, My "on" times increased by approx' 50%, my side effects, = mainly dyskenesia virtually disappeared, and even in my "off" times I was= more mobile than before. I have now been on Cabaser since November '97 = and the benefits are still as stated, with no obvious downside. Hope this is of some use. Regards, Nigel [log in to unmask]