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Thanks for the suggestion, Tom. I have already decreased my Sinemet intake by 50%, which the Mirapex demanded - I have tried and been unsuccessful at decreasing Sinemet any lower. There is that very fine line between too much and too little Sinemet that I don't seem to be able to hit on. I also have tried titrating Sinemet in the liquid form.......... Everyone on the listserv who knows me, knows that I am far from being a quitter. I can't stand to admit defeat ---- but I'm crying UNCLE on Tasmar... Terrie 43/16