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Hello, I was wondering if anyone else has noticed this: My husband (aged 57, PD 14 years) takes only sinement and eldepryl. He takes 3 100/25 tablets each day, broken in half, each dose taken 2 hours apart. He has always had a difficult time smoothing out his dosage levels. He will peak about 1 hour after taking a dose, be "on" for maybe 25 minutes, then be off again. When he is off, he is very slow and stiff but at least he is relatively safe. When "on", he is very diskenetic and often falls, sometimes badly. He NEVER falls when he is off. I was wondering if anyone else has noticed this phenomenon of falling only when on. I might also add, for those interested in amantadine, Iain did try this some years ago. He said that he did feel better on it, but it made him hallucinate. That was not much fun and we took him off. Thanks in advance - how wonderful to have a resource like this to call upon. Barb Bates Barbara Duffin-Bates Program Support Vaughan Memorial Library Acadia University 1-902-585-1378 [log in to unmask]