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I take 20mg in the morning and 20mg at night of imipramine, for depression and have not seen much relief except it seems to keep me tired all the time. I keep hearing about zoloft does anyone know if that is better and makes you less tired all the time. also I have been on amantadine for four months and it seems to help with the tremors a slight amount. I take 10mg in the morning and 10 at night. I have been on sinemet for four years at max dose twice a day have never seen much for that one. I also take selegelline twice a day.. the only thing that has shown me anything is this amantadine. I use to take permax however it almost shut down my kidneys.. Does anyone have better suggestions? Jim J. 54/4 [log in to unmask] P.S. I love all the information on the list