John - you asked: >>> Jbtwelv <[log in to unmask]> 05/21/98 12:39pm >>> >>>If you can recall the reference to difficulty with estimating time (how long something will take to get done), or if anyone can offer further evidence or documentation of this phenomenon<<< John Bachman John: The human brain has an internal system for measuring the passage of time. The system involves the substantia nigra and the brain striatum. Both of these areas are implicated in PD. The neurotransmission of dopamine acts to push the watch forward. Lesions of the substantia nigra and/or the striatum slow or stop the timekeeping system. Levodopa has been shown to restore an accurate sense of time. For more info read: Science magazine, 1996, issues 271 and 272. Stephan 53/7