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Janet, Thanks for the information re Zoloft and Eldepryl. I am now more confused. My neurologist and my psychiatrist recently took me off Effexor (because of side-effects), and put me on Zoloft. According to the psychiatrist, Zoloft produces less side-effects than other antidepressants. Of course, as you well know, everyone does not react the same to these drugs. Forgive me if I I'm wrong....I'm trying to remember exactly what my neurolgist and my psychiatrist told me re the above. It seems there are two types of MAO inhibitors: MAO-a inhibitors and MAO-b inhibitors. Eldepryl is a MAO-b type, which I believe produces less adversive reactions when combined with certain drugs or food. Another factor that supposedly affects the overall situation is the dosage amount of the antidepressant. Both doctors told me that the dosage of antidepressant I was taking would not cause problems with the Eldepryl. (This concerned Effexor, Paxil, and Zoloft.) I am presently taking 50mg. of Zoloft. I know that Emory did a study on PD patients a few years back to see how well they did on Paxil. I think this subject is very confusing for PWP. If there are any PD doctors out there, perhaps you could enlighten us on this subject. Sincerely, Rosemary Russell 50, 4 1/2 yrs. ([log in to unmask])