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hi margaret what kind of sinemet have you taken? CR or 'regular'? how long ago? have you had any food/drink yet today? i think kees's query about vomiting is a good one particularly if you have taken the CR version if you have taken the regular sinemet all at once particularly on an empty stomach i would suggest consuming a lot of protein all day to block the sinemet's access to the carrier which takes it to the blood/brain barrier milk in particular is supposedly really effiicent at 'grabbing all the seats on the bus' and leaving sinemet behind do you have someone who can stay with you for the day? dyskinesia will probably be a major problem but keep a sharp eye out for any hallucinations/delusions or anxiety as well just my humble opinion as a sister warrior in the pd battle let us know how you are doing i will monitor the list mail regularly all day love janet janet paterson aka calendar control supervisor 51/10 - sinemet/selegiline/prozac - [log in to unmask] quotations: http://newww.com/cgi-bin/do_cal?c:newvoice pwp event calendar: http://newww.com/cgi-bin/do_cal?c:pwpc