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Hi, This is my first mailing to the PARKINSN group. I am 51 years old and live in Lincolnshire (near Boston) in England and have been suffering from PD for the past nine years although I was mistakenly diagnosed with M.E. for all that time! I have been taking Amantadine for the past three months, since finally being diagnosed in March as hosting PD in my brain. At first I took 100mg twice a day (7 am and 1 p.m.) combined with an anticholinergic, Benhexol, 2mg 3 times daily. I found that I was felt better reducing the Benhexol to 1 mg three times a day at four hourly intervals. As I suffered severe depression, the second opinion I sought on my GP's advice recommended that I stop the Benhexol and started me on an Amitriptyline working slowly up to 150 mg before bed at night. I must admit that this has altered my life. I now sleep through the night for the first time in years and the anticholinergic attributes of the Amitriptyline seem to last throughout the next day and balance the Dopaminergic enhancing effects of the Amantadine. My worries are that the effects of the Amantadine are supposedly short lived (in terms of months) and the brain becomes habituated. Is this true? Does increasing the dosage beyond 300mg a day ineffectual? I have found that I am more easily confused and less able to figure things out mentally .... is this a side effect of Amantadine or a symptom of PD? Should I worry? I have many other questions that I would like to ask but don't want to bother all you good people with FAQ's, covering old ground yet again. Is there a good WWW site that can deal with them; although I'd rather speak to PWP who have been there, read the book, seen the movie and can give an opinion based on experience ............. Regards to all and more power to PWP.... Jon Blakeman-Shead