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Han's, This is positive, proven incontrovertible fact? I've never heard it expressed so positively - and clearly - before. We should, if we can, stay away from most Sinement for the first 10-15 years. I was diagnosed in early 1995 and they have me on 4 25/100's a day of it plus 6 mg of Mirapex - and i'm been doing very poorly, especially in he mobility department. I sounds like i should at least cut back some and see what happens ???