Thanks to all who gave us their thoughts on delaying Sinement. I don't yet know what the heck to do. My first reaction was compromise - take half of what I was taking, which was 4 - 25/100's. But 2 is less than the 75mg that is supposed to be the minimum dosage that produces any effect. So I would be left with Mirapex and Selegiline. (I took Amantadine for 3 years, quitting in Feb.) Aaaaaarrggggh. The first thing I need is a new neuro, which I'm working on right now. How hard is it to live with dyskensia? I mean, does it typically last 2 hours a day, 10? Or impossible to generalize? How about a range? Can you time it, or at least predict it's onset? Thanks! Bruce