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Ronald, Thanks for your reply below to my question. Aliza is using 25/100 CR pills. How does this affect your sugggestion below? I did not know that regular pills are 1/3 more effective than CR pills.Previously,Aliza was taking half pills of 25/250 or 12.5/125 which using 1/3 reduction corresponds to about 67mg of levadopa with the 25/100 CR pills.This is almost a 50 percent reduction in levadopa as compared with the regular pills.This may account for her increased symptoms with the CR.Is my reasoning correct? Gil ----------------------------------------------- Date: Tue, 9 Jun 1998 13:24:28 +0000 From: "Ronald F. Vetter" <[log in to unmask]> Subject: Re: Carbidopa >Meanwhile,Aliza's symptoms are worsening and she feels off after about 4 hours >which suggests going to half a pill every four hours corresponding to 25mg/hr >of Levadopa and 150mg/day of Carbidopa which is over the 125mg/day "maximum >effective dosage" given by Roche but well within your 300mg/day "maximum safe >quantity for effective protection" limit given in your paper.What to do? >Your suggestion of juggling 10/100 with 25/100 is feasible. >How about alternating 10/100 with 25/100 every four hours? >This would keep the Levadopa rate of 25/mg/hr and reduce the Carbidopa rate to >105mg/day in place of 150mg/day. >Gil Lieberman If you use 25/100 regular carbi-/levodopa tablets, the dosage of levodopa will be about 1/3rd more effective than using CR. I suggest that trying half a 25/100 every 3 hours or so might well supply the needed levodopa and cost less as well as provide lower peak concentration. Ronald Vetter 1936, dz PD 1984, carbidopa/levodopa, Mirapex, selegiline [log in to unmask] Ridgecrest, California http://www.ridgecrest.ca.us/~rfvetter