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Brian Collins wrote: >On Thu 11 Jun, Gil Lieberman wrote: >> Ronald, >> Thanks for your reply below to my question. >> >> Aliza is using 25/100 CR pills. >> How does this affect your sugggestion below? >> I did not know that regular pills are 1/3 more effective than >> CR pills.Previously,Aliza was taking half pills of 25/250 or 12.5/125 >> which using 1/3 reduction corresponds to about 67mg of levadopa with >> the 25/100 CR pills.This is almost a 50 percent reduction in levadopa >> as compared with the regular pills.This may account for her increased >> symptoms with the CR.Is my reasoning correct? snip >Hello Gil. I am not sure that you have quite absorbed the role of Carbidopa >(or Benserazide in Madopar tablets). I will just list the main points to try >and clarify the setup. snip >4. The theory about Controlled release tablets is that they spend longer in >the blood stream, and thus are exposed for a longer period of time to attack. I >have never seen the proof of how much this affects the levodopa getting to the >brain - My instinct is to believe a loss of 5% rather than the quoted 30%. the reality seems to be that CR binder dissolving rate is quite variable. only a portion of the tablet is dissolved. the data in the human testing report is the origin of this information. http://www.ridgecrest.ca.us/~rfvetter/levoplas.html has some data and conjecture regarding this. Ronald Vetter 1936, dz PD 1984, carbidopa/levodopa, Mirapex, selegiline [log in to unmask] Ridgecrest, California http://www.ridgecrest.ca.us/~rfvetter