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Hello, everyone--I just joined this group today, and am thankful I found you. My husband was diagnosed with Parkinsonism and depression three years ago. He never had a tremor, or shook at all. His walking was slow(shuffling), and his demeanor was that of someone quite depressed.(This from the doctors). Until about a year ago, he was functioning pretty well on Sinemet (25/100) and Effexor. I guess they started losing potency about that time, and he was treated by the psychiatrist and neurologist, trying to determine what he needed. To make a long story short, the neurologist tried four new drugs: Mirapex, Requip, Permax and Tasmar, none of which did him any good. I asked to up his dose of Sinemet, and was told to go ahead, which I did. He seems better, but his biggest problem is the dementia that goes along with the disease. He is also taking Xanax (0.25mg) with each dose of Sinemet --about equal to 1 1/4 tablet daily. Does anyone know if this combination affects the dementia he has, or is the dementia a by-product of PD. I keep searching the net for answers, and hope that someone can give me a clue. Thanks for listening. Next time I'll try to be brief! Marilyn