Hello Jonathan, I have been taking Cabaser since Nov' 97 in conjunc= tion with Madopar, Amantadine and selegeline. Since going on to cabaser = (as a replacement for Pergolide, which was not working for me) life has = become much easier, with a noticeable increase in "On" times, and perhaps= even better, an almost total disappearance of the dreaded dyskenesia.Per= sonally speaking it was the most significant improvement in my quality = of life since I developed P.D. 10 years ago. I don't know where you live = Jonathan, but if you live in the 'States you may find it difficult to obt= ain Cabaser, but if you can get it I hope it works as well for you as it = has for me. Best Wishes, Regards, Nigel, Age 43, diagnosed 1989, Taking Madopar, Cabaser, Selegeline, Amantadine, Amitriptyline. [log in to unmask]