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I know this has been discussed before, but I came across this report which may be of interest. In Am J Psychiatry 150:11, Nov 1993 A letter to the editor: Visual hallucinations occur commonly in PD with levodopa treatment. My colleagues and I recently encountered a patient with PD who developed hallucinations related to fluoexetine (prozac) treatment. This patient who had bilateral idiopathic PD with early dementia,experienced rare (twice monthly) visual hallucinations on a regime of 50mg carbidopa and 200 mg levodopa and 2.5 mg bromocriptine (both twice daily) prior to treatment. When Prozac (20 mg) was added every other morning, visual hallucinations occurred twice daily (other symptoms did improve). These included seeing people in his house, temporarily associated with visual illusions of bugs. There were no auditory hallucinations or paranoia and no other medical explanations for the hallucinations. Several months later, the Prozac was discontinued and the hallucinations completely resolved within several weeks. The regime of levodopa was increased to four times daily without precipitation of hallucinations. The theory behind this reaction is that (simply) Prozac augments dopamine activity . They ended by saying "caution may be advised when treating PD patients with Prozac."