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I came across the following and wondered if this applies to Parkinsons as well... Fatigue In Multiple Sclerosis Patients Treatable WESTPORT, Nov 22 (Reuters) - The fatigue that so often affects multiple sclerosis patients is effectively relieved with use of the drug amantadine, according to a report in the journal Neurology. In a study of 93 MS patients with severe fatigue, Dr. Lauren B. Krupp, and colleagues at State University of New York at Stony Brook compared the efficacy of amantadine with the efficacy of another drug used to treat fatigue called pemoline and with placebo . Dr. Krupp found that patients taking amantadine reported a significantly greater reduction in fatigue than patients taking pemoline or placebo. Dr. Krupp adds a word of caution. Not everyone responded to amantadine, so while amantadine should be tried first, pemoline should be considered "a second line of defense," she says. Neurology 1995;45:1956-1961. -Westport Newsroom 203 221 7648 -- Judith Richards, London, Ontario, Canada [log in to unmask]