> From: Judith Richards <[log in to unmask]>
> Subject: NEWS:Mirapex May Help Reduce Tremor
> June 17, 1998
>
> Company Press Release
> SOURCE: Pharmacia & Upjohn
snip...
>
The most common side effects of Mirapex taken
> with levodopa observed in clinical trials for advanced-stage Parkinson's
> disease were postural hypotension (low blood pressure caused by a change
> in posture), dyskinesias (impaired movement), extrapyramidal syndrome
> (involuntary movements), insomnia, dizziness and hallucinations. All
> patients should be informed that postural hypotension may occur more
> frequently during initial treatment, and hallucinations can occur at any
> time during the course of treatment.
How I hate jargon . I have always maintained that it was designed by
people who knoe very little but are trying to appear knowledgeable .
I have been posting on the list using :
dyskinesia = involuntary movement
bradyskinesia = slow/impaired movement
I believe that everyone else was using these terms in this way . Am I
wrong ? It would explain why I am so much out of step with other list
menbers . If we cannot even get the language right what hope is there
for understanding ?
This is in no way a reflection on Judith who continues her excellent
task of providing the list with important info .
The piece of jargon I have yet to work out is " dopamine agonist ".
Here is this articles definition.
P&U, Mirapex belongs to a class of compounds called dopamine agonists,
which stimulates dopamine receptors in the brain.
My dictionary defines " agonist " as " one engaged in the struggle "
. Can "dopamine agonist " be used of a substance that boosts the
dopamine effect ( Like suppressing the MAO B that destroys the
dopamine ) ? Can it be used of a substance
that substitutes for/mimics dopamine ?
I am far from certain that I am the only person for whom " dopamine
agonist " is too vague to have any real meaning ,except that it
appears to help the dopamine neural transmission pathways of the
brain , in some vague and undefined way . This seems to include
all/most PD medication .
Please Judith keep presenting all other peoples reports I am a sponge for
any info but I find jargon difficult especialy when I cant get a
handle on it .
> --
> Judith Richards, London, Ontario, Canada
> [log in to unmask]
>
>
peace
Alastair ( [log in to unmask] )
