Marilyn: You have certainly come to the right place, there are many very supportive and knowledgeable people here. Don't worry that your post was to long, it's nice to get to know you and this is really here for discussion. My husband also has PD, and it has been a challenge. Depression can be a part of PD, but the masked face and slowness of movement, etc. also can just be PD. We had a psychiatrist speak to our support group a few years ago and he addressed this very thing. He described how someone who presents with classic symptoms of depression appears and acts. We all thought he was describing PD. There are a lot of drugs available and it takes some time to figure out which ones are doing the most to help. It is an ongoing process. Over time it is not at all unusual for increases to be needed in Sinemet. You didn't mention it but there is a controlled release simemet that can be very helpful for some people. It sounds like your hubby is taking a lot of anti-depressant, but you should discuss this with your doctor. We've found that keeping track of the medications being taken and various reactions helps. Of course you have to also keep track of what you've eaten, stress levels, etc. It's amazing all the different things that can impact the medications effect. It really isn't all that difficult after you get started. It helps us when we go to see the neuro. We can usually point out patterns or he will see patterns where adjustments can be made. Welcome Aboard. Carolyn CG Deon 58/15