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l.rauha wrote: > > Nurses at the National Institutes of Health have asked me to field your ideas regarding the best ways you have found to take Sinemet. Specifically, they are interested in your experiences with different liquids, such as grapefruit juice, milk, carbonated beverages or caffeine drinks or with chewing the tablets (but not dissolving as in liquid Sinemet). If you have any interesting findings to report, please forward your ideas to Marge Gillespie, R.N., at: > [log in to unmask] > They thank you in advance for your cooperation. > Lisa Millen 56/11 Dear Lisa and Marge: My wife Barbara was hospitalized twice about three years ago for a colon resection and then for an obstructed bowel. As a Parkinsonian, she was taking Sinemet every 2 1/2 hrs. and Permax 3 times a day, and the timing for the Sinemet dosage does not allow much for deviation, otherwise rigidity sets in and the patient is most difficult to deal with. Luckily for us my wife was a registered nurse and I was an analytical pharmaceutical chemist with the FDA. I was distraught to see the nurses at Arlington hospital trying to juggle all the medications on time, including Amantidine and Aldactone. The doctor in charge allowed US to bring the medication from home and dispense them as needed. When she was fed by tube, I borrowed a mortar and pestle, ground the Sinemet, added a few cc's of water and pushed it into the feeding tube through a 50 cc syringe, rinsed the mortar again with a little additional water until all the Sinemet was pushed into the tube. When the tube was removed, Barbara just took the Sinemet with water (our neuro insists that it is the best way) and drink enough of it to make sure it does not stick in the gullet. I hope this helps. Michel Margosis