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Trish, If I had read both post before answering the first one I could have saved time. No, he can't take sinemet CR with his meals, both CR and regular Sinemet react to protien the same way. Kathryanne Holden is our advisor on what and when to eat it. Hope she will jump in here and help you out jjjane http://www.parkinsonalliance.net/medical/palross/palross.htm >Dad is taking Sinemet CR 25/100 and would like to know if he can take it with >a meal. He knows he's not supposed to take Sinemet with a meal, but he would >like to know about Sinemet CR since it is time released. Trish http://www.parkinsonalliance.net/medical/palross/palross.htm