John! With your contribution of the 4th. July, you invite a feedback from anyone else who has experienced the gastro-intestinal problems that I recognized only too well! I am a 69/11 PD. The daily drugs mix does not include Mirapex. Amongst others are:- Jumaxel 2x 5mg - aid to extend the "on" phase (Selegeline/Eldepryl) Madopar "DR" 250 1'000mg = 800mg levodopa (Sinemet) ReQuip 14mg - dopamine agonist (Ropinirole) Aldozone 25 mg - to reduce excess body water A minimum intake of 3 quarts liquid is programmed and usually met. To me, what is especially frustrating is the feeling of absolute inability to exercise any control. I am no longer in charge of myself! The efforts made when the cramps announce themselves without warning are painful and tiring; as more often than not they are unsuccessful in achieving a satisfactory result, indeed the end result always seems to be a surprise and is never the "right" volume of discharge to earn a moment or two's well earned peace! All this results in an even stronger "inner resistance" against a wish to do anything or go anywhere. A usually positive approach to PD is put to a severe test. My report may not be of headline quality but perhaps, there may be a phrase, a word or a thought that could act as a stimulus. The offer of a "relief" medicine would be the best reward to everyone having to face up to the vicious and ever present PD. Should you wish any further detail or information from me, then do please ask. With every good wish RAE [log in to unmask](Rae Paterson)