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Dear Trish, For the best effect, Sinemet CR should be taken 30-45 minutes before meals, just like regular Sinemet. If your Dad has nausea with Sinemet, he can take it with meals, but it will not be as effective, as the food will slow down its early absorption. If your Dad is experiencing on-off fluctuations, it would be best for him to take CR prior to meals. My very best regards, Kathrynne Trish Scarmuzzi wrote: > Dad is taking Sinemet CR 25/100 and would like to know if he can take it with > a meal. He knows he's not supposed to take Sinemet with a meal, but he would > like to know about Sinemet CR since it is time released. Trish -- Kathrynne Holden, MS, RD "Nutrition you can live with!" Medical nutrition therapy http://www.nutritionucanlivewith.com/ Tel: 970-493-6532 // Fax: 970-493-6538