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Camilla, >We also have been told that CR can be taken with meals, precisrely because >of the delayed release. It's confusing, but that seems to be the case. > I too have been told that - but my personal experience is that Sinemet CR also works best if taken 20 - 30 mins before eating. Of course there will be people who have an opposite experience. It falls to each of us to find what works for us. After all dealing with PD is an art form, not a science. Dennis.