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Hi John Faus, I too have swelling of my feet and ankles. I currently take 1mg Mirapex 3 x"s a day. Also my right ankle aches at times. My primary care phy. put me on a small dose of lasix, and increased my lanoxin sllightly. However the swelling continues. I try to elevate my feet higher than my heart but seldom can find the time for this. Sorry i couldn't help you morre I don't take sinemet. margie [log in to unmask]