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Didi, You ask what would happen should your aunt be weaned off Sinemet. The simple and unavoidable answer is that her Parkinson's symptoms would return to whatever extent her PD has progressed. She has, however, many more options other than just stopping the Sinemet. You do not mention in your posting which form your aunt's side effects take (though I am assuming the involuntary twitching and writhing movements known as dyskinesia); or whether she is taking other PD medications; or whether she is under the care of a neurologist or GP. In the absence of this information some of the suggestions I am about to make may be redundant. My suggestions are that your aunt: 1. Consult the best neurologist she has access to. If possible the neurologist should be a movement disorder specialist. 2. Establish with the neurologist a suitable mix of the many drugs now used in the treatment of PD. If she and her neurologist are unable to improve her condition by adding to/adjusting her drug regime she might consider discussing with him/her her suitability as a candidate for surgery. I hope this is of some help. Dennis. +++++++++++++++++++++++++++ Dennis Greene 48/11 [log in to unmask] http://members.networx.net.au/~dennisg/ +++++++++++++++++++++++++++