On Wed 01 Jul, Camilla H.Flintermann wrote: > Myron Greene writes: > > (care of Camilla Flintermann) > > Please reply to: > > Myron Greene, <[log in to unmask]> > > > > Hello Myron, It is a relatively rare event to read of someone's experience which I feel is relevant to my situation. When you get to my position (Age 58; Diagnosed 19 years ago; first symptoms 25 years ago ) and pause for a moment to look at what is going on, it seems a bit lonely out there. I was put on Parlodel early in my PD life, with very similar results to you: I became very neurotic, and gave my wife a hard time for 6 months, until I fortuunately realised something was wrong- gave up Parlodel at that instant, and in 2 weeks I was back to normal. You may know that I have used my personal experience to write a computer program which helped me to get the absolute maximum effectiveness out of Sinemet (or Madopar in my case). I currently take around 800 mg of levadopa per day, and 4 mg Pergolide per day. Pergolide I know gives some people problems but for me it has been fine, doing just what it claims to do: take more Dopamine or Dopamine agonist without provoking worse dyskinesia. The problem is that having achieved such accuracy in analysis, I can also look into the near future... and that shows that I am running out of time. Above 4 mg , the side effects of Pergolide can be pretty severe: I will find out how bad in about one to two years. I am getting a rather cynical attitude about Mirapex - it seems to me that anything which requires so much self-sacrifice must be a bit suspect. I hope I do not have to consider using it. I feel that too many people jump desperately from one to anothee of the Dopamine agonists, even though they are getting good performance from their present drug. It becomes a question of fashion, which is no way to go. Let us know how you get on Regards, -- Brian Collins <[log in to unmask]>