My husband is taking fosamax for osteoporosis. He has been taking it for about six weeks and has had no reactions. The only problem is the inconvenience of having to take it first thing in the morning before anything else including other medications and then having to wait a minimum of half an hour (but better one to two hours) in order to get the most benefit from the drug. It prevents more calcium from leaching out of the bones and perhaps allows some to be added. Also, he is not to go back to bed but to remain upright because it can cause an ulcerated esophogus. He also takes sinimet and mirapex. Rosemary Dexter cg for Dex 76/5