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Fosamax is a problem where administartion is concerned I too have to take synthroid at the same time and usually an early riser can take it sometimes 4 oclock in the morning. Besides PD I have scoliosis develope over the past year and along with my stoop has been playing havoc on my shoulder muscles especially in the evening when the PD meds. are beginning to hit rock bottom.After a bone density test a couple of months ago found I had severe osteaporosis in spine and hips.So am taking Fosamax , Metacalcin via nasal spray,vit.A&D for the Osteaporosis one synthroid for thyroid ,eldepryl,sinemet,sinemet cr.and Mirapex. Non seem to have had any diverse reaction with each other. The Mirapex certainly has been a big plus for me not really lengthening the "ON" period but quality time is really improved beyond expectation. The only trouble now is not to plan too much during on time as exhaustion still lerks in every corner. Good luck with the Fosamex I did leave it off for a few days when experienced dry and slight cough but was due to pollen, sincerely , Margaret, love hope and faith for a cure.