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I believe you misunderstood. What you say would only be true if you just take 1/2 of the tablet. You will have a slightly faster acting response by breaking the tablet and ingesting both halves. But that would negate having a CR (Controlled Release) tablet in the first place. A person might as well take just a plain Sinemet with some slightly different makeup. J. Darwin Hawkins, Test Engineering Phone: (316) 523-2804 (W), (316) 788-2322 (H) Fax: (316) 523-3130 Work E-Mail: [log in to unmask] Home E-Mail: [log in to unmask] > ---------- > From: KF Etzold[SMTP:[log in to unmask]] > Sent: Thursday, July 23, 1998 1:02 PM > To: Multiple recipients of list PARKINSN > Subject: Braking a Sinemet CR > > I want to add to the discussion of the effects of breaking a CR in > half. It > seems to me that the conclusions are opposite to what > has been described before. Assume that the rate of dissolution of the > pill is > proportional to the area. The we need to compare the area befrore and > after > breaking the pill. Consider a half section: the area before consists > of the top > and bottom surfaces and the edge strip. However, the end is not > exposed > because the pill is not broken yet. Now consider after: the area which > used to > consist of the top, > bottom and edge strip is now reduced to the oval area where the break > is. I > would argue therefor that the new area is signifantly smaller than > before, > almost by a factor of two. > Therefore the dosage would be *reduced* by the same factor. > K-F >