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Marling, Depressing yes - downright scary - undoubtedly, but that's the way the raw facts read. If indeed most people were facing that in their future funding the search for a cure would be no trouble. As written your message relies for its considerable impact on saying just that - PD is bad and the odds are you are going to get it, so lets get it before it gets you. Unfortunately (in strategic terms) the facts are that most people will never suffer from PD. Using the figures you quote in your message if 200 of every 100,000 people have PD, 99,800 don't. If I was placing a bet on any single individual getting PD I'd have to bet against it as it is close to a sure thing that they won't. And its not going to change soon. Even at the annual incidence of 20 per 100,000, it is going to take 5000 years before everyone is a PWP. Marling - you have written a great letter - but you are going to have to find another opening paragraph. Dennis