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Hi Brian, I'm with you. I understand your view and I will not let things get too bad before I try some medicaion. My doctor did suggest that I start with an agonist first. Do you think that is not the right approach? If I start on Requip and don't get much (or any) relief would it not be a good idea to then start the levadopa and be able to take a lesser amount because of taking the agonist also? I think that is the direction my doc is leaning. I have been following your post's for several months now and have visited your website. Sounds like you have some very good theorys on using sinemet. Lanier Maddux 62/2