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J.Eldon Green wrote: > > I was told today at a support group meeting that if you cut a sinemet CR pill > in half you destroy the CR. Is this true and if so where is it published? > Eldon Green > Tampa Bay I don't recall exactly where, but I have seen a comment that Sinemet CR broken in half will "kick in" sooner, have a higher peak concentration, and a shorter half-life than when swallowed whole. You will notice that the tablet is scored for that purpose. All this makes sense because the rate at which any solid substance dissolves depends upon the surface area exposed, and two halves obviously have more surface area than a single whole tablet. The difference between Sinemet CR and ordinary Sinemet, I suspect, is that tablets of the former employ a different inert binder, maybe cornstarch or some such stuff, that dissolves more slowly. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013