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I want to add to the discussion of the effects of breaking a CR in half. It seems to me that the conclusions are opposite to what has been described before. Assume that the rate of dissolution of the pill is proportional to the area. The we need to compare the area befrore and after breaking the pill. Consider a half section: the area before consists of the top and bottom surfaces and the edge strip. However, the end is not exposed because the pill is not broken yet. Now consider after: the area which used to consist of the top, bottom and edge strip is now reduced to the oval area where the break is. I would argue therefor that the new area is signifantly smaller than before, almost by a factor of two. Therefore the dosage would be *reduced* by the same factor. K-F