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Gina, Many years ago when I was taking parlodel, I developed the same sort of blotchiness on my legs, plus extreme sensitivity to cold- prolonged exposure to cold air caused what looked like a 'heat' rash. It stopped when I stopped the parlodel. More recently, my ankles swelled up - and that was while taking permax. My doctor switched me to mirapex, and the swelling went down. But the dyskinesia went up, Hilary Blue P.S. My husband was manic depressive, and he couldn't take lithium - because of a severe skin reaction. He took mellaril - which as a side effect causes a tremor - for which he took artane. My 12 year old daughter appears to have inherited the manic depressive gene - and we have to be very careful what medication she is given in case she has inherited my PD = apparently the one set of medications can have adverse effects on the other. (What a pair of Blue genes) She was taken off depakote recently - because of a skin rash - and put on respardil. (I think that's how you spell it) Hilary Gina Cass. wrote: > > Hi Pete: > Thank you for your kind email of the "Wonders of PD Meds". I feel something is > causing a thing on my feet and calves. They started as black/.blue marks which > now they are more blue. My calves are bright red and feel like you are > wearing a sock constantly. The skin is taut, shiny, and there is aching under > the skin alot of the time. . I also take Eskalith (Lithium), > Depakote, Paxil, Synthroid, Seroqual, Vasteric I think that's all. I'm really > interested in your adventures with Cogentin. Right now the problem is the > "rash" maybe its a rash it is blue. > Gina > 47/7 mos Anything else would be appreciated about PD I try to read, ask dr no > help