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My husband's nuero prescribed a new drug, Zomig, for my migraines and they work great!! They do nothing for the pain, but somehow get rid up them at the point of origin. I have to idea how they work. They are expensive, but I only take them when I get a migraine, and usually only need one before the headache is gone. I used to have them for 2 or 3 days and would sometimes wind up having Murph take me to the emergency room they got so bad. I don't know if they would interact with PD meds, but you might ask about it. Bev c/g; Murph 56/7