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Here are a couple of items from my CSR files: Merello M et al; Mov Disord 1997;12:506-508: By a questionnaire survey of 312 PD patients, they found that about half feel better for an hour or more after sleeping, to the degree that they could skip or delay the morning dose of levodopa. Hogl B et al; Neur 1998;50:1332-1339: Some PD patients feel better and have fewer motor symptoms on waking in the morning, despite the prolonged deprivation of levodopa, while others do not. To study this, they gave motor tests to 10 patients with sleep benefit and 10 without. The former group, as expected, did better on the morning motor tests but was more susceptible to "off" spells between levodopa doses. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013