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Dear Listmembers, <fontfamily><param>Times New Roman</param><bigger><bigger> Some remarks in this thread ask for more attention. Nancy B. said: "he always takes sinemet before retiring". Darwin Hawkins, however: " I don't take any within four hours of bedtime". I remember that some time ago I was asthonished by Dennis Greene, who said he sometimes needed a sinemet to be able to sleep. For me it is impossible to sleep on sinemet. The question that now arises is: is there any relation between being=20 able or not to sleep with sinemet and having the" benefit of sleep". Bruce found a reported relation between "sleep benefit" and much interdose symptoms.This is in concordance with the reported relations I found between sleep benefit and duration of illness. Like Barb.Mallut, I can't mop floors during the "benefit of sleep" period . If I try to be active the benefit disapears soon and symptoms like freezing and dystonia appear. But unlike Barb it is not only an effect of pallidotomy., but I have the impression the sleep benefit is increased by pallidotomy. I can lengthen the period by abstaining from physical activity. I do feel, like Tom Riess, this period is better than a normal "on" period. The difference is that being "on" thanks to sinemet, I feel never totally relaxed. The effect of sinemet is not only that I am able to move, but also that I have to. If I resist, the first result is dystonia, which may or may not be followed by freezing . When in the benefit of sleep period I can be relaxed and feel quite normal. The fact that I am not able to be physically active is a thing I know but I don't feel it. The literature about sleep benefit says it is common and reported by 30% to 40% of the patients. It has no relation to quality of sleep and it is more frequently reported by young -onset patients.=20 Thinking over things like this , I hope to see some clustering of symptoms that would divide us PWP's into type A and B or X and Y. Does=20 any of the research-wise members know whether a factor analysis is ever tried on patients and symptoms?=20 </bigger></bigger></fontfamily><bigger>Regards, Ida</bigger> -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]