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Dear Gina, In response to this and your reply to Anne, let me tell you a bit of my history. Many years ago, (about 12 or 13) I was taking sinemet, amantadine and parlodel. I developed many of the symptoms you talk about on the legs, including extreme heat and cold sensitivity, and a sort of networking of the fine capillaries on the surface of the skin of the legs - which you can still see tho it has faded. A change in doctors resulted in dropping parlodel and amantadine, starting eldepryl (brand new on the market then) which also brought about an enormous reduction in the amount of sinemet - and complete reversal of the symptoms.............until last year I started taking permax with my sinemet,. Now I have never bruised easily so I don't have the pyrotechnic display you have, but my ankles disappeared, and my feet and legs were just one block of pain, with my normally dainty ankles as thick as my calves. Switch to merripax a few months ago and hey presto, my ankles regain their beauty, I have lost 30 pounds weight (though that may be the constant high energy dyskinesia)..........and I fall asleep like clockwork every day at 11am and 3pm regardless of where I am - at therapy, or exercise class, today in synagogue......and of course I can't sleep at night. Sorry, I think I just dropped off again -- So you pays your money and you takes your choice! If I exist there must be others out there like me. Hilary Blue 49/16 Gina Cass. wrote: > > Dear Debbie: > > Oh, I would apprecaite any info you get, as the 3 musketeers can only not get > along. So, while they are not getting along, I get no info. I will be making > some large changes very soon. My health and life depend on it, not their's. > I will be awaiting your reply. > I take Sinemet and Permax. > > TTFN > Gina > 47/8 mos