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My husband, Ken also takes sinemetCR at bedtime. In fact, because he has shy- drager syndrome and sinemet tends to lower blood pressure, he takes his largest dose at bedtime. He also takes a Benedryl at bedtime. Before he started taking sinemet at bedtime, he tended to jerk and shake at night, but now he usually sleeps all night without moving and without waking. He sleeps in a hospital bed in the same room as I do, and we both sleep pretty soundly. We attribute his sleeping well to the fact that the sinemet keeps him from becoming rigid and tight muscled during the night. Barbara Smith,cg/Ken/70/17