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Terry, Just finished the following someone else. It sounds like it might fill your request. In a message dated 8/10/98 6:56:07 PM Central Daylight Time, [log in to unmask] writes: << PD medications seem to affect people in quite different ways, so what benefits one may not benefit another PWP. Indeed, today's spectacular success can fizzle out tomorrow and return in full form the next day. Mostly, the effectiveness of meds seems to be regulated by the degree of motility of the gut more than anything else. Every new medication is an adventure in trial and error. >> You are right about the need to do things by trial and error. Sometimes a little book learning helps also. : I hope you find this information useful: Catachol O Methyl Transferase (COMT).is one of two enzymes responsible for the breakdown of dopamine... Thus, when taking Tasmar , a COMT inhibitor, one can/should take less L-dopa because the dopamine is not being destroyed as fast with the COMT enzyme inhibited . Parlodel is a quite different medicine from Tasmar...It is a dopamine agonist , meaning to some extent it does what dopamine does. Regards, WHH 55/19