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I wrote last night because my mother Joyce (68/1 year) is having a tough time right now and her doctor suggested that she may have some other Parkinsonian disease. After receiving reading some informative pieces suggested by some on this list, it seems to me more and more that she has PD. She is not, however, having great success with her drugs. Her doctor is reducing her Requip so that she is off it completely within a week (so that she can start something else). She started today reducing her dosage from 21 mg./day (7 mg 3x/day) to 5mg in the morning, 5 mg in the afternoon, and 2 mg. at night. She hasn't taken the last dosage because she's having a terrible day with internal tremors and wants to talk to the doctor (MDS) about taking 5 mg. tonight rather than 2 mg. First, this seems to indicate that the drugs ARE doing her some good. What I think is confusing the issue is that my mother doesn't (never has) have clear on/off periods. However, I don't think one can conclude from this that the drugs aren't working. So my next question is: Isn't it possible to say the drugs are working without feeling them kick in? Any thoughts? Debbie White [log in to unmask]