DRUGS THAT MAY INTERFERE IN THE MANAGEMENT OF PARKINSON'S DISEASE
Published by Young Parkinson's Support Network of California
Revision: 04/95 YPSN of CA
This list has been reviewed by our medical advisor. Always notify your
physician of any adverse effects of drug therapy.
WARNING TO USERS OF ELDEPRYL CONTEMPLATING SURGERY
Sandoz Pharmaceuticals has issued a warning of reports of fatal interactions
between Eldepryl (Selegiline Hydrochloride) and merperidine known as
Demerol, and other trade names. Patients contemplating surgery are advised
to bring this notice to the attention of their physician. Further
information can be obtained from pharmacies - ask for prescribing
information - or contact Sandoz Pharmaceuticals at 1-800-631-8184.
OTHER DRUGS WITH POTENTIAL TO ALTER THE SYMPTOMS OF
PARKINSON'S DISEASE
Some drugs employed in the treatment of non-neurologic conditions may alter
or influence the brain's dopamine system. These drugs, when given to a
Parkinson's patient, have the potential to alter the symptoms of Parkinson's
disease. Should a physician prescribe a drug on this list, the patient
should make sure the prescribing physician:
1.is aware of the patient's Parkinson's disease and the drug's potential
for altering disease symptoms,
2.is aware of the patient's current drug therapy for Parkinson's disease
and any other disease(s),
3.explains to the patient both the benefits and the potential side
effects of the drug therapy and what action to take for adverse side
effects.
DRUG TYPE:
Trade Name Generic Name Notes
Antidepressant: Any antidepressant +
Asendin Amoxapine selegeline (Eldepryl)
Nardil Phenelzine may worsen PD
Nardil Phenelzine
Parnate Tranylcypromine
Triavil (Contains Perphenazine)
Antipsychotic: Clozaril (clozapine) &
Haldol Haloperidol Zyprexia (olanzapine)
Loxitane Loxapine are the only ones safe
Mellaril Thioridazine for use in PD
(Mellaril in low dosage ok)
Moban Molindone
Navane Thiothixene
Orap Pimozide
Prolixin Fluphenazine
Permitil Fluphenazine
Serentil Mesoridazine
Sparine Promazine
Stelazine Trifluoperazine
Taractan Chlorprothixene
Thorazine Chlorpromazine
Tindal Acetophenazine
Trilafon Perphenazine
Vesprin Triflupromazine
Antivomiting/Gastrointestinal: Worsen PD symptoms
Compazine Prochlorperazine
Reglan Metoclopramide
Torecan Thiethylperazine
Blood Pressure:
Raudixin Rauwolfia Serpentina
Miscellaneous:
Serpasil Reserpine
Post-Op Medication:
Harmonyl Deserpine
Moderil Rescinnamine
Rauverid None
Rauwiloid None
Wolfina None
Possible Potential:
Aldomet Alpha-methyldopa
Buspar Buspirone
Lithobid Lithium
NO OPIATES These utilize the same dopamine receptors that levodopa does and
worsen PD symptoms.
Anesthesia and PD:
Droperidol should not be used with patients with PD. It blocks the dopamine
receptors and might occupy the GABA receptors leading to an imbalance
between dopamine and acetylcholine neurotransmitters. Dopamine, serotonin
and norepinephrine may be adversely affected.
