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Michel, With reference to your posting below,I have some questions which I hope you or someone else can answer. 1.What does being "on" refer to with different PWPs? 2.How does a CG recognize when a PWP is "on"? 3.How is "on time" defined? 4.How did the patients know they could reduce levadopa dosages? 5.How did Barbara know it was working well? 6.How advanced is Barbara's PD and which of her PD symptoms were alleviated? Note: Behind what is bothering me is a perception that Tasmar only can help PWPs with certain types of PD symptoms and at certain advanced stages.I am struggling to understand which symptoms can be alleviated.Presumably,the terms on and off refer to particular PD symptoms,e.g.diskinesia,dystonia,bradykinesia,bradyphrenia,etc. Gil Lieberman,CG for Aliza,PD 2/95. ----------------------------------- Date: Tue, 18 Aug 1998 23:58:56 -0400 From: Michel Margosis <[log in to unmask]> Subject: Re: tolcapone > On average, patients taking the drug had more than 2 extra hours of ``on`` time daily, > Adler and colleagues report. These patients were also able to reduce the > dose of levodopa they were taking by more than 20%. > Indeed, it has thus been working well with Barbara who takes 100 mg Tasmar twice a day, and has been able to reduce the Sinemet 25/100 taken 7 times a day to 3-4 times a day, extending the time between dose from 2.5 to 4-5 hrs, and has likewise reduced her Permax by about 20%. But we are still awaiting the cure!!! Michel Margosis